Journal: bioRxiv

Article Title: Intermittent theta burst stimulation at personalized targets reduces the functional connectivity of the default mode network in healthy subjects

doi: 10.1101/646265

Figure Lengend Snippet: A schematic representation of the study design. In session 1, we obtained the informed consent and collected the information from Structured Clinical Interviews (SCI). After this we acquired a structural (T1-weighted) and functional (rsfMRI) image. During rsfMRI, the subjects were instructed to fixate at a ‘+’ and mind wander, while their open eyes were monitored by eye tracking. Personalized target were found using each subject’s rsfMRI as has been described elsewhere . Using online neuronavigation, we delivered real or sham iTBS, in a counterbalanced and pseudo-randomized fashion, at 80% of resting motor threshold. Baseline and three post-iTBS rsfMRI scans were acquired. The subjects also completed the Positive and Negative Affect Schedule (PANAS) both before and after the sessions, and a visual analog scale (VAS) for perceived effects of iTBS on mental state and scalp sensation at the end of the sessions.

Article Snippet: We navigated to the personalized left DLPFC target using an online neuronavigation system (Visor 1 software, ANT Neuro, Enschede, Netherlands).

Techniques: Functional Assay